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KMID : 0903520050480010098
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2005 Volume.48 No. 1 p.98 ~ p.102
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Deveolopment of Biologically Active Compounds from Edible Plant Sources-XII. Flavonol Glycosides from Trigonotis peduncularis Benth and its hACAT1 Inhibitory Activity
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Yang Hye-Joung
Song Myoung-Chong
Bang Myun-Ho
Lee Jin-Hee
Chung In-Sik
Lee Youn-Hyung
Jeong Tae-Sook
Kwon Byoung-Mog
Kim Sung-Hoon
Kim Dae-Keun
Park Mi-Hyun
Baek Nam-In
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Abstract
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The MeOH extracts obtained from whole plant of Trigonotis peduncularis Benth. were solvent fractionated using EtOAc, n-BuOH and water, successively. The EtOAc and n-BuOH fractions gave four flavonol glycosides through application of silica gel and octadecyl silica gel (ODS) column chromatographies. The chemical structures of the flavonol glycosides were determined by the interpretation of several spectral data including 2D-NMR as kaempferol-3-O-b-D-glucopyranoside (astragalin, 1), kaempferol-3-O-a-L-rhamnopyranosyl (1→6)-b-D-glucopyranoside (nicotiflorin, 2), quercetin-3-O-a-L-rhamnopyranosyl(1→6)-b-D-glucopyranoside (rutin, 3), quercetin-3-O-b-D-glucopyranoside (isoquercitrin, 4). The flavonoids have been first isolated from this plant. Nicotiflorin (100mg/ ml) showed 68.3±1.2% of the inhibitory effect on hACAT1(human Acyl CoA: cholesterol transferase 1) activity.
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KEYWORD
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Trigonotis peduncularis, flavonol glycoside, astragalin, nicotiflorin, rutin, isoquercitrin, hACAT1
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